| Customization: | Available |
|---|---|
| CAS No.: | 850140-73-7 |
| Formula: | C28h29clfn5o7 |
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Description Afatinib dimaleate is a salt form of afatinib. Afatinib is a second-generation oral irreversible inhibitor of the ErbB family of tyrosine kinases.
Mechanism of Action Afatinib downregulates ErbB signaling by covalently binding to the kinase domains HER4, resulting in irreversible inhibition of tyrosine kinase autophosphorylation; it Also inhibits transphosphorylation of HER3. Afatinib Approved as Monotherapy for the Treatment of EGFR Tyrosine Kinase Inhibitor (TKI) Naïve Adults with Locally Advanced or DefinitionChEBI: Obtained by Combining Afatinib with Two Molar Equivalents of Maleic Acid maleate. For the first-line treatment of patients with metastatic non-small cell lung cancer.
| BIBW2992 DiMaleate Basic information |
| Description Mechanism of Action |
| Product Name: | BIBW2992 DiMaleate |
| Synonyms: | BIBW2992 DiMaleate;BIBW2992-MA2;Afatinib (diMaleate);Afatinib (diMaleate), BIBW2992;2-ButenaMide, N-[4-[(3-chloro-4-fluorophenyl)aMino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(diMethylaMino)-, (2E)-, (2Z)-2-butenedioate (1:2);(2E)-N-(4-[(3-chloro-4-fluorophenyl)aMino]-7-{[(3S);Afatinib double Maleate;Afatinib (BIBW2992) Dimaleate |
| CAS: | 850140-73-7 |
| MF: | C28H29ClFN5O7 |
| MW: | 602.02 |
| EINECS: | 810-416-1 |
| Product Categories: | Inhibitors;tyrosine kinase receptor inhibitor;850140-73-7 |
| Mol File: | 850140-73-7.mol |
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Analysis
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Specification
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Result
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Test method
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Physical Description
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Appearance
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White Powder
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White Powder |
Visual
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Odor
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Characteristic
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Characteristic
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Organoleptic
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Particle size
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90% pass 80 mesh
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90% pass 80 mesh
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80 Mesh Screen
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Chemical Tests
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Assay (Lutein)
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99%
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90.15%
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HPLC
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Loss on drying
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5.0% Max
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1.82%
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5g/105ºC/2hrs
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Ash Contents
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5.0% Max
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1.12%
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2g/525ºC/3hrs
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Residual Solvents
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50.0 ppm, Only Ethanol
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<30.0 ppm
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/
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Heavy metals
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5.0 ppm Max
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<3.0 ppm
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AAS
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Lead
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3.0 ppm Max
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<1.0 ppm
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AAS
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Arsenic
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3.0 ppm Max
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<1.0 ppm
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AAS
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Microbiology Control
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Total Bacteria Count
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1,000cfu/g Max
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<280cfu/g
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AOAC
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Yeast & Mold
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100cfu/g Max
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<10cfu/g
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AOAC
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Coliform
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30.0 MPN/g Max
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<3.0 MPN/g
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AOAC
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Conclusion
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Complies with the standards.
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General Status
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Non-GMO, ISO Certificated.
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Afatinib Dimaleate is a salt of afatinib (BIBW2992) (B377000), an aminotoluidine substituted quinazoline derivativeChemicalbook for the treatment of cancers and diseases of the respiratory tract, lung, gastrointestinal tract, bile duct and gallbladder. An aminomethylquinazoline that irreversibly inhibits EGFR and HER2 kinase activity.
1.Packed by 25 kg, pp woven bag with inner per bag Packed by 500kg/1000kg jumbo bag or as your requirement
2.prompt shipment after receipt of your order confirmation
3.Transit could be DHL,UPS,TNT,EMS,Fedex,and so on.
4.For mass orders, it will be delivered by air or sea.
5.Depending on your location, please allow 1-5 business days for your order to arrive.
6.For small order, please expect 3-7 days by UPS DHL EMS.
7.For mass order, please allow 5-8 days by Air, 15-30 days by Sea.
Lapatinib Ditosylate |
Olaparid |
Erlotinib | Baricitinib | Cabozantinib |
| Ibrutinib | LOXO 101 | LOXO 195 | Imatinib | Imatinib mesylate |
| MK-4827 | Niraparib | Gefitinib | Lapatinib | AZD9291 |
Shandong Baovi Energy Technology Co., ltd
Shandong Baovi Energy Technology Co., ltd is located in Jinan city, Shandong province, was founded in 2003.
Products include solvents, antifreeze, anticorrosion, management, chemicals intermediates, etc., widely used in agriculture, food sanitation and other fields.
FAQ
Q: Are you trading company or manufacturer ?
A: We are factory.
Q: How long is your delivery time?
A: Generally it is 7-10 working days after payment.
Q: Do you provide samples ? is it free or extra ?
A: Yes, we could offer the sample for free charge but do not pay the cost of freight.
Q: What is your terms of payment ?
A: TT,LC,DA,DP or as customer's requirement.
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